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High Purity Nitroxoline 99.5% - China Suppliers & Factory for Pharmaceutical Antibiotic Intermediate
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Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (2).jpg
Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (1).jpg
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Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (2).jpg
Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (1).jpg
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High Purity Nitroxoline 99.5% - China Suppliers & Factory for Pharmaceutical Antibiotic Intermediate

Nitroxoline (5-nitroquinolin-8-ol) is a highly effective urinary antibacterial agent, targeting both gram-positive and gram-negative bacteria commonly associated with urinary tract infections. As a leading product from our factory in China, Nitroxoline is trusted by suppliers worldwide for its reliability and potency in combating urinary ailments. Ensure optimal care and health with our high-quality Nitroxoline, sourced from reputable suppliers and manufactured in state-of-the-art facilities in China
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    Product Detail

    Product Parameters

    Product Name Nitroxoline
    CAS NO 4008-48-4
    Structure Nitroquinoline.jpg
    Molecular formula C9H6N2O3
    Purity Over 99.5%
    Other product names 5-Nitro-8-quinolinol, 8-Hydroxy-5-nitroquinoline, 5-Nitro-8-hydroxyquinoline, 5-nitroquinolin-8-ol
    Molecular weight 190.16

    In vitro activity

    Using spectrophotometric fluorescence assay, Nitroxoline can significantly reduce the degradation of extracellular DQ collagen IV in all tested cancer cell lines. Nitroxoline can significantly reduce real-time monitoring of tumor cell invasion and decrease the invasive growth of multicellular tumor spheroids, which can be used as a three-dimensional vitreous model of tumor invasion. In vitro angiogenesis experiments, Nitroxoline can significantly reduce the formation of endothelial tubes.

    In vitro activity

    Nitroxoline significantly inhibited tumor growth,angiogenesis and metastasis in LPB fibrosarcoma and MMTV PyMT breast cancer mouse models.

    Kinase experiment

    In Vitro Kinase Assays : The potency of SP600125 towards kinases, including MPS1, JNK, and Aurora kinase A, is determined based on the specific measurement of radioactive phosphotransfer to the substrate. For each enzyme, the absolute Km values for ATP and the specific substrate are initially determined and each assay is then run at optimized [ATP] (2·αKm) and [substrate] (5·Km) concentrations. MPS1 activity is measured using 5 nM of MPS1 recombinant protein in 50 mM HEPES pH 7.5, 2.5 mM MgCl2, 1 mM MnCl2, 1 mM DTT, 3 μM NaVO3, 2 mM β-glycerophosphate, 0.2 mg/mL BSA, 200 μM P38-βtide substrate-peptide (KRQADEEMTGYVATRWYRAE), and 8 μM ATP with 1.5 nM 33P-γ-ATP. Ten serial 1:3 dilutions (from 30 μM to 1.5 nM) of SP600125 are tested and IC50 determined.
    DJI_0701gqj4H0A5610fa5

    Cell experiment

    Cell suspension are seeded in the wells of an E-plate 16 according to the manufacturer's instructions. After seeding, the CI is monitored every 15 min. After ∼10 h (MCF-10A neoT and MMTV-PyMT), 14 h (U-87 MG) or 24 h (LPB), when the cells are in their log phase of growth, 50 μl of the compound or 0.1% DMSO is added, and the experiment allowed to run for 72 h. Once every 24 h the medium is replaced with fresh medium containing the inhibitor or suitable control to prevent cell death due to medium depletion. Compounds and their concentrations are: nitroxoline (5 μM) and CA-074 (5 μM) for all cell lines other than MCF-10A neoT cell line, where nitroxoline was used at 2.5 μM. All measurements were performed in quadruplicate. (Only for Reference)

    Frequently Asked Questions

    What is the CAS number and molecular formula of Nitroxoline?

    Nitroxoline has the CAS number 4008-48-4 and the molecular formula C9H6N2O3, with a molecular weight of 190.16.

    What other names is Nitroxoline known by?

    It is also referred to as 5-Nitro-8-quinolinol, 8-Hydroxy-5-nitroquinoline, 5-Nitro-8-hydroxyquinoline, and 5-nitroquinolin-8-ol.

    What is the purity level of this product?

    The purity level of Nitroxoline is over 99.5%.

    How does Nitroxoline perform in in vitro activity assays?

    Nitroxoline significantly reduces the degradation of extracellular DQ collagen IV across all tested cancer cell lines. It also reduces tumor cell invasion in real-time monitoring, decreases the invasive growth of multicellular tumor spheroids, and reduces endothelial tube formation in angiogenesis experiments.

    What are the observed effects of Nitroxoline in tumor mouse models?

    In LPB fibrosarcoma and MMTV PyMT breast cancer mouse models, Nitroxoline significantly inhibits tumor growth, angiogenesis, and metastasis.

    What concentrations of Nitroxoline are recommended for cell experiments?

    Based on reference studies, a concentration of 5 μM is used for most cell lines, whereas a concentration of 2.5 μM is utilized specifically for the MCF-10A neoT cell line.