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Nitroxoline: Effective Oral Antibacterial for UTI Treatment - China Suppliers & Factory
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Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (2).jpg
Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (1).jpg
Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (2).jpg
Nitroquinoline as an oral antibacterial drug for the treatment of urinary tract infections (1).jpg

Nitroxoline: Effective Oral Antibacterial for UTI Treatment - China Suppliers & Factory

Nitroxoline (5-nitroquinolin-8-ol) is a highly effective urinary antibacterial agent designed to combat urinary tract infections caused by both gram-positive and gram-negative bacteria. As a trusted product, it is widely used in China and sourced from top suppliers who ensure quality and efficacy. Our factory adheres to stringent manufacturing processes to deliver Nitroxoline that meets the highest standards, making it a preferred choice for healthcare professionals dealing with urinary infections. Choose our Nitroxoline to provide effective relief and support for urinary health
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    Product Detail

    Product parameters

    Product Name Nitroxoline
    CAS NO 4008-48-4
    Structure Nitroquinoline
    Molecular formula C9H6N2O3
    Purity Over 99.5%
    Other product names 5-Nitro-8-quinolinol, 8-Hydroxy-5-nitroquinoline, 5-Nitro-8-hydroxyquinoline, 5-nitroquinolin-8-ol
    Molecular weight 190.16

    In vitro activity

    Using spectrophotometric fluorescence assay, Nitroxoline can significantly reduce the degradation of extracellular DQ collagen IV in all tested cancer cell lines. Nitroxoline can significantly reduce real-time monitoring of tumor cell invasion and decrease the invasive growth of multicellular tumor spheroids, which can be used as a three-dimensional vitreous model of tumor invasion. In vitro angiogenesis experiments, Nitroxoline can significantly reduce the formation of endothelial tubes.

    In vitro activity

    Nitroxoline significantly inhibited tumor growth,angiogenesis and metastasis in LPB fibrosarcoma and MMTV PyMT breast cancer mouse models.

    Kinase experiment

    In Vitro Kinase Assays : The potency of SP600125 towards kinases, including MPS1, JNK, and Aurora kinase A, is determined based on the specific measurement of radioactive phosphotransfer to the substrate. For each enzyme, the absolute Km values for ATP and the specific substrate are initially determined and each assay is then run at optimized [ATP] (2·αKm) and [substrate] (5·Km) concentrations. MPS1 activity is measured using 5 nM of MPS1 recombinant protein in 50 mM HEPES pH 7.5, 2.5 mM MgCl2, 1 mM MnCl2, 1 mM DTT, 3 μM NaVO3, 2 mM β-glycerophosphate, 0.2 mg/mL BSA, 200 μM P38-βtide substrate-peptide (KRQADEEMTGYVATRWYRAE), and 8 μM ATP with 1.5 nM 33P-γ-ATP. Ten serial 1:3 dilutions (from 30 μM to 1.5 nM) of SP600125 are tested and IC50 determined.
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    Cell experiment

    Cell suspension are seeded in the wells of an E-plate 16 according to the manufacturer's instructions. After seeding, the CI is monitored every 15 min. After ∼10 h (MCF-10A neoT and MMTV-PyMT), 14 h (U-87 MG) or 24 h (LPB), when the cells are in their log phase of growth, 50 μl of the compound or 0.1% DMSO is added, and the experiment allowed to run for 72 h. Once every 24 h the medium is replaced with fresh medium containing the inhibitor or suitable control to prevent cell death due to medium depletion. Compounds and their concentrations are: nitroxoline (5 μM) and CA-074 (5 μM) for all cell lines other than MCF-10A neoT cell line, where nitroxoline was used at 2.5 μM. All measurements were performed in quadruplicate. (Only for Reference)

    Frequently Asked Questions

    What is the CAS registry number for Nitroxoline?

    The CAS number for Nitroxoline is 4008-48-4.

    What are the molecular formula and weight of Nitroxoline?

    Nitroxoline has a molecular formula of C9H6N2O3 and a molecular weight of 190.16.

    What are some other names for Nitroxoline?

    Nitroxoline is also known as 5-Nitro-8-quinolinol, 8-Hydroxy-5-nitroquinoline, 5-Nitro-8-hydroxyquinoline, and 5-nitroquinolin-8-ol.

    How does Nitroxoline affect tumor cells and angiogenesis in vitro?

    In vitro, Nitroxoline significantly reduces the degradation of extracellular DQ collagen IV, decreases real-time tumor cell invasion and the growth of multicellular tumor spheroids, and reduces endothelial tube formation.

    Does Nitroxoline show efficacy in animal models?

    Yes, in vivo experiments show that Nitroxoline significantly inhibits tumor growth, angiogenesis, and metastasis in LPB fibrosarcoma and MMTV PyMT breast cancer mouse models.

    What concentrations of Nitroxoline are typically used in cell experiments?

    In cell experiments, Nitroxoline is used at a concentration of 5 μM for most cell lines, and at 2.5 μM specifically for the MCF-10A neoT cell line.